For a short intercity connection, direct buses from Comitán de Domínguez to San Cristóbal de las Casas are the simplest option.
Quick answer
Typical current journey: about 2 hours 10 minutes
Current fare examples: about MXN 82–93
Current operators: ADO, OCC and Cristóbal Colón depending on departure
Arrival labels: Portal Oriente or San Cristóbal bus-station labels depending on listing
Current route
Current late-August listings show multiple direct departures throughout the day. Several examples take 2h10 and are priced around MXN 82–93.
Use this as a current snapshot only. Search your exact date before travel.
Departure in Comitán
Comparison platforms use labels such as Parada de Autobús or Transporte terminal. The exact location attached to your ticket is more reliable than the generic stop name shown in a search result.
Open the map location from your confirmation before departure.
Where do you arrive in San Cristóbal?
Current listings use Portal Oriente and other San Cristóbal bus-station labels depending on service.
If you are continuing to accommodation in Centro, you may need a walk or short taxi ride.
For terminal-name context, see San Cristóbal Bus Stations & Terminals.
For the final trip to your accommodation, see Getting Around San Cristóbal.
Sources